This handbook offers a state-of-the-art overview of quantitative science and technology research. It focuses on the development and application of indicators derived from data on scientific or scholarly publications and patents. It comprises 34 chapters written by leading specialists in the various sub-domains. These chapters deal with theoretical and methodological issues, illustrate applications, and highlight their policy context and relevance. Authors present a survey of the research topics they address, and show their most recent achievements. The 34 chapters are arranged into 5 parts: Disciplinary Approaches; General Methodology; The Science System; The Technology System; and The Science–Technology Interface. The Editor’s Introduction provides a further specification of the handbook’s scope and of the main topics addressed in its chapters. This handbook aims at four distinct groups of readers: – practitioners in the field of science and technology studies; – research students in this field; – scientists, scholars and technicians who are interested in a systematic, thorough analysis of their activities; – policy makers and administrators who wish to be informed about the potentialities and limitations of the various approaches and about their results.